Joint rejuvenation represents a paradigm shift in modern orthopedics, focusing on the preservation and regeneration of joint structures rather than early joint replacement. At Dr. Anupam Khandelwal’s practice, we offer scientifically backed, minimally invasive solutions that are tailored to your individual joint health profile. The goal is simple yet powerful: restore function, relieve pain, and delay or avoid prosthetic intervention.

Understanding Joint Degeneration

Joint degeneration involves progressive cartilage loss, synovial inflammation, and subchondral bone changes—often seen in osteoarthritis, post-traumatic arthritis, and sports injuries. Traditional therapies focused on symptomatic relief, but joint rejuvenation shifts the focus toward biological repair, mechanical realignment, and cellular regeneration.

Latest Advances in Joint Rejuvenation

1. Orthobiologics & Cellular Therapy

Dr. Anupam Khandelwal incorporates leading regenerative options in treatment protocols of patients selected for Joint rejuvenation and repair treatment protocol :

1.1 Platelet-Rich Plasma (PRP)

Rich in growth factors like PDGF, TGF-β, and VEGF. Evidence from peer-reviewed trials demonstrates improved pain scores and functional outcomes in mild to moderate osteoarthritis (Di Matteo et al., Am J Sports Med, 2016).

1.2 Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSCs)

Shown to stimulate chondrocyte regeneration, improve joint space width, and modulate inflammatory cytokines (Jo et al., Stem Cells, 2014; Chahal et al., Arthroscopy, 2019).

1.3 Amniotic and Umbilical Tissue Allografts

An emerging frontier in non-cellular regenerative medicine. These matrices contain collagens, hyaluronic acid, and anti-inflammatory proteins that support joint recovery and pain reduction.

2. Visco-supplementation

2.1 Hyaluronic acid injections

High-molecular-weight hyaluronic acid injections replenish joint lubrication, improve shock absorption, and restore synovial fluid homeostasis.

3. Arthroscopic Joint Preservation

Minimally invasive procedures for selected patients include:

Cartilage debridement
Microfracture for focal defects
Meniscal repair or reshaping
Synovectomy for inflammatory control

4. Image-Guided Precision Interventions

Real-time ultrasound-guided intra-articular injections ensure targeted delivery of biologics with greater efficacy and reduced complications.

Multimodal Joint Rejuvenation Protocol

Each patient is evaluated holistically with a structured protocol:

Advanced imaging: MRI with cartilage mapping, dynamic ultrasound
Biomechanical evaluation
Personalized rehab with neuromuscular re-education
Nutritional optimization for collagen and joint matrix synthesis
Pharmacologic adjuncts (e.g., collagen peptides, glucosamine sulfate)

Indications for Joint Rejuvenation

You may be a candidate if you have:

Grade I–III osteoarthritis (Kellgren-Lawrence scale)
Focal chondral or osteochondral lesions
Early post-traumatic arthritis
Recurrent joint effusion without mechanical locking
Pain unresponsive to standard physiotherapy but not severe enough for replacement

Evidence-Based Support

Key clinical studies supporting joint rejuvenation therapies:

Di Matteo B, et al. PRP vs. hyaluronic acid: A systematic review. Am J Sports Med. 2016;44(2):388-398.
Jo CH, et al. Intra-articular injection of mesenchymal stem cells for cartilage regeneration. Stem Cells. 2014;32(5):1254-1266.
Chahal J, et al. The role of stem cells in treating knee OA: A review. Arthroscopy. 2019;35(5):1756-1775.
Kon E, et al. Injectable systems for intra-articular delivery of biologics in early OA. J Clin Med. 2020;9(6):1730.

Patient Testimonial

“I was told I’d need a knee replacement within a year. At 47, that was not an option I was ready for. After undergoing PRP therapy and a customized rehab plan under Dr. Khandelwal, I’m back to hiking with minimal discomfort. My MRI shows cartilage stability and no need for surgery yet. I’m beyond grateful.”
— Mr. R***** S****, Pune
(Patient treated for early-stage medial compartment knee osteoarthritis)

Why Choose Dr. Anupam Khandelwal?

Dr. Khandelwal brings a rare dual expertise in joint preservation and complex orthopedic trauma, allowing for a nuanced understanding of both surgical and non-surgical management. With a focus on evidence-based care and global academic engagement, he ensures every patient receives precise, personalized, and progressive treatment.

Fellowship-trained orthopedic surgeon
Member, Indian Orthopedic Association(IOA) , Association of Orthopedic Surgeons of Indore (AOSI)
founder, Indore Joint Club (IJC)
Contributor to ongoing studies in regenerative orthopedics and biomaterials

Consultation & Referrals

If you’re exploring alternatives to joint replacement or wish to enhance your current orthopedic care, we invite you to book a detailed consultation. Referrals from family physicians and physiotherapists are welcome.

📍 Visit us at: www.dranupamkhandelwal.com
📞 Call: +91-8818814030
📧 Email: info@dranupamkhandelwal.com

Preserve Your Joints. Reclaim Your Mobility. Rejuvenate Your Life.